Impermanence
Utnapishtim's declaration that "There is no permanence" means for humans that our world is never constant, and we are always forced to adjust to it. This is because nature is always changing (this can be seen with the ice ages and the climate change that enabled agriculture to develop), and we need to adjust to nature or else we will die off as a species. As people our minds are always developing and our bodies are always changing to fit the new demands of our environment. Our world illustrates this impermanence in big ways like the consistent changing of language and in smaller ones like how no two days are exactly the same. Even Enkidu, who was created by the gods as the only creature who could challenge part-deity Gilgamesh, had to leave the earth and die. How people get up and go about their business with this knowledge of impermanence is certainly not an easy question to answer. I think a lot of people consciously ignore the fact that they will di...